Tuberculostatic Derivatives of p-Aminobenzoic Acid. II. Derivatives of 2-Halogeno-4-aminobenzoic Acid.
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چکیده
منابع مشابه
Separation of p-Aminobenzoic Acid Derivatives
According to the literature, p-aminobenzoic acid (PAB) is excreted in the urine mostly as the free acid and its N-acetyl derivative; the remaining part is eliminated conjugated with glucuronic acid and as p-aminohippuric acid (PAH) (Ellinger & Hensel, 1914'; Hensel, 1914; Cohen & McGilvery, 1946; Salassa, Bollman & Dry, 1948). There is no agreement concerning the formation of PAH. Thus, Beyer, ...
متن کاملTHE ANTIBACTERIAL ACTION OF DERIVATIVES AND ANALOGUES OF p-AMINOBENZOIC ACID
The bacteriostasis induced by the sulfonamide drugs is reversed by p-aminobenxoic acid (PAB) in appropriate concentrations (1). It is now well established that PAB is a normal constituent of cells (2) and that the bacteriostatic effects of the sulfonamides are explicable in terms of their structural similarity to PAB (3). The precise rble of PAB in cellular metabolism has yet to be clarified bu...
متن کاملThe In Vitro Effects of N-Substituted p-Aminobenzoic Acid Derivatives upon Sulfonamides.
The discovery by Woods (1940) that small amounts of p-aminobenzoic acid could block the antibacterial effects of the sulfonamides served to stimulate a number of investigations on sulfonamide p-aminobenzoic acid relationships. Woods's initial finding soon led to the observations that many derivatives of p-aminobenzoic acid also exhibited antisulfonamide activity. Keltch et al. (1941) demonstrat...
متن کاملThe impact of environment and resonance effects on the site of protonation of aminobenzoic acid derivatives.
The charge distribution in a molecule is crucial in determining its physical and chemical properties. Aminobenzoic acid derivatives are biologically active small molecules, which have two possible protonation sites: the amine (N-protonation) and the carbonyl oxygen (O-protonation). Here, we employ gas-phase infrared spectroscopy in combination with ion mobility-mass spectrometry and density fun...
متن کاملTHE ISOLATION OF p-AMINOBENZOIC ACID FROM YEAST
The present investigation is primarily concerned with the isolation of p-aminobenzoic acid from yeast. The presence of this substance in yeast was adumbrated by Woods (1) who made the important discovery that. this aromatic amino acid possesses the unique propcity of antagonizing the bsctcriostat~ic action of sulfanilamidt? and that the component. of yeast extracts which exerts a similar antisu...
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ژورنال
عنوان ژورنال: Acta Chemica Scandinavica
سال: 1949
ISSN: 0904-213X
DOI: 10.3891/acta.chem.scand.03-0013